在消化道恶性肿瘤中,结肠癌颇为常见,根据肿瘤原发部位的不同,分为左右半结肠癌,这两者在流行病学特性、分子生物学特性、临床表现、基因检测结果及治疗预后等多个维度上均存在差异。中医方面左右半结肠癌也存在一定的差异。遵循“方从法出,法随证立”的原则,在选用方剂与药物时,左右半结肠癌展现出特定的用药区别。通过归纳其内在规律并深入剖析左右结肠癌在中医证候类型上的差异,为个体化治疗提供新思路。Among malignant tumors of the digestive tract, colon cancer is relatively common. Based on the primary site of the tumor, it is classified into right-sided and left-sided colon cancer, which differ in various dimensions such as epidemiological characteristics, molecular biological features, clinical manifestations, genetic testing results, and treatment prognosis. There are also certain differences between right-sided and left-sided colon cancer in Traditional Chinese Medicine (TCM). Following the principle of “prescriptions derived from treatment methods, and treatment methods established according to syndromes,” specific medication differences emerge in the selection of prescriptions and herbs in right-sided and left-sided colon cancer. By summarizing the underlying patterns and deeply analyzing the differences in TCM syndrome types between right-sided and left-sided colon cancer, new ideas for individualized treatment can be provided.