早发性卵巢功能不全(premature ovarian insufficiency, POI)主要以围绝经期症状,月经失调(月经稀少、甚至闭经)为主,伴有高促性腺激素、低雌激素水平等为主要表现,对女性的危害主要是提前出现的低雌激素状态以及生殖机能的提前衰退。中医认为,肾藏精贮天癸,主生殖,为先天之本,天癸至则月事如期而至,若肾精亏损,冲任血海空虚,不能按时盈满而溢则可见月经后期、月经量少甚至闭经等问题,因此肾精亏虚,天癸竭是引起POI发病的根本病机。朱鸿秋教授认为该病的发生以肾虚为主导,但临床中常兼有肝郁、脾虚、痰湿、瘀血,在治疗上根据月经周期分期论治,随证加减,并结合中医特色治疗综合调理,注重情志疗法,身心同治,必要时中西医结合诊治,临床疗效显著。Premature ovarian insufficiency (POI) is mainly characterized by perimenopausal symptoms, menstrual disorders (scanty menstruation or even amenorrhea), accompanied by high gonadotropin and low estrogen levels, etc. It is harmful to women because of the early appearance of a low estrogen state and the early decline of reproductive functions. According to Chinese medicine, the kidney stores essence and sexual stimulant essence, and is the main reproductive agent, which is the foundation of the innate nature, and when sexual stimulant essence arrives, menstruation occurs on schedule. If the kidney essence is deficient and the blood and organs are empty, and if they cannot fill up and overflow on time, then it can be seen that menstruation is late, and the amount of menstruation is small, and even amenorrhea is even a problem, etc. Therefore, the deficiency of the kidney essence and the depletion of sexual stimulant essence is the fundamental pathogenesis that causes the onset of POI. Prof. Zhu Hongqiu believes that the disease occurs with kidney deficiency as the leading cause, but in clinical practice, it is often accompanied by liver depression, spleen deficiency, phleg
目的:运用知识图谱分析寿胎丸的研究现状、研究成果、研究热点和发展趋势,为该领域的进一步研究提供参考。方法:检索中国知网数据库自2000年1月1日至2023年8月31日收录关于寿胎丸的文献,应用Cite Space 6.1.R2对文献的作者、机构、关键词进行计量学分析,并绘制、分析相关知识图谱。结果:研究一共纳入文献599篇,年发文量在2008-2016年迅速增长,发文最多的作者为雷磊(37篇),共形成3个研究团队。发文量最多的机构是湖南中医药大学(57篇)。主要研究方向是寿胎丸的加减应用、临床疗效和临床试验等方面。当前的研究热点是寿胎丸治疗自然流产的临床疗效和机理研究,以及寿胎丸与性激素的相关性研究,基础研究逐渐引起该领域研究者的关注。结论:运用寿胎丸加减诊疗疾病的临床观察仍是目前研究的热点,药物代谢及机理层面的深入研究将成为未来的研究重点,多元化的治疗方案亦是未来临床研究的趋势。未来应重视寿胎丸研究的延续性及深入性。如开展多中心、大规模、高质量的临床研究以提供高级别的循证医学证据;深入开展相关基础研究以丰富寿胎丸的现代医学研究内容。
